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Diovan

 

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  • Common use
  • Dosage and direction
  • Precautions
  • Contraindications
  • Possible side effects
  • Drug interactions
  • Missed dose
  • Overdose
  • Storage
  • U.S. Sale and Prescription Policy
  • Disclaimer
  • Common use

    Diovan (generic name: valsartan) is a modern angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension), manage certain cases of chronic heart failure, and improve survival after a heart attack (myocardial infarction). By selectively blocking the AT1 receptor for angiotensin II, Diovan prevents blood vessel constriction and reduces aldosterone effects, which lowers systemic vascular resistance, helps blood vessels relax and widen, and decreases the workload on the heart. The net effect is a sustained reduction in blood pressure and improved hemodynamics that support heart function.

    Clinical uses include:

    • Hypertension in adults and in pediatric patients aged 6 to 16 years. Lowering blood pressure reduces the risk of stroke, heart attack, and kidney complications.
    • Heart failure with reduced ejection fraction (HFrEF), typically in patients who are intolerant of ACE inhibitors or as part of guideline-directed therapy to reduce hospitalizations and improve symptoms.
    • Post–myocardial infarction, to reduce cardiovascular mortality and improve outcomes when started after hemodynamic stabilization.

    In addition to its core indications, clinicians may consider valsartan in patients with proteinuric kidney disease, particularly when ARBs are preferred over ACE inhibitors due to cough or angioedema. For patients with diabetes and hypertension, valsartan helps control blood pressure and may slow kidney damage when used as part of comprehensive care that includes diet, exercise, lipid management, and glucose control.

    Diovan is FDA-approved, available as a branded product and as generic valsartan. It is also available in combination products such as valsartan/hydrochlorothiazide for patients requiring multi-mechanism control. Its once-daily dosing, favorable side effect profile compared to some alternatives, and cardioprotective benefits make it a cornerstone therapy in evidence-based cardiovascular care.

    Dosage and direction

    Take Diovan exactly as prescribed by your healthcare provider. The dose, frequency, and titration schedule depend on the condition being treated, coexisting medical issues, and your response to therapy. Diovan can be taken with or without food; try to take it at the same time each day to support adherence.

    • Hypertension (adults): Typical starting dose is 80 mg or 160 mg once daily. Based on blood pressure response, the dose may be adjusted between 80 mg and 320 mg once daily. Some patients benefit from combination therapy with a thiazide diuretic when monotherapy is insufficient.
    • Hypertension (pediatrics 6–16 years): Dosing is weight-based and usually starts at 1.3 mg/kg once daily (up to 40 mg), titrated to a maximum of 2.7 mg/kg (up to 160 mg) as needed. Pediatric dosing should be guided by a clinician experienced in pediatric hypertension.
    • Heart failure: Common starting dose is 40 mg twice daily, then titrated at intervals (usually 1–2 weeks) to 80 mg and up to 160 mg twice daily as tolerated. Monitoring blood pressure, kidney function, and potassium is essential during titration.
    • Post–myocardial infarction: Start as early as clinically appropriate after stabilization, often 20 mg twice daily, then increase to 40 mg, 80 mg, and up to 160 mg twice daily as tolerated to achieve target doses shown to improve outcomes.

    Swallow tablets whole with water. Do not crush or chew unless your prescriber advises an alternative form. If you are using an oral suspension for pediatric dosing, ensure it is prepared and measured accurately according to the pharmacist’s instructions.

    Important administration tips:

    • Consistency matters. Take Diovan at the same time daily. If you use other blood pressure medications, discuss spacing to reduce dizziness.
    • Hydration and salt intake can influence blood pressure and kidney function. Sudden dehydration from vomiting, diarrhea, or aggressive diuresis may increase the risk of low blood pressure or kidney side effects; contact your clinician if this occurs.
    • Do not change your dose or stop Diovan abruptly without medical guidance, as this may worsen blood pressure or heart failure control.

    Precautions

    Before starting Diovan, tell your healthcare provider about your medical history and all medications you take. The following considerations help ensure safe, effective use:

    • Kidney function: ARBs can affect renal hemodynamics. Patients with chronic kidney disease (CKD), renal artery stenosis, or those taking NSAIDs may be at increased risk for changes in kidney function. Baseline and periodic monitoring of creatinine and eGFR are recommended.
    • Potassium levels: Valsartan can increase serum potassium. Use caution with potassium-sparing diuretics (e.g., spironolactone, eplerenone, amiloride), potassium supplements, or salt substitutes containing potassium. Monitor potassium after dose changes or when adding interacting drugs.
    • Liver function: Use with caution in moderate hepatic impairment; avoid in severe hepatic dysfunction or cholestasis unless specifically directed by a specialist.
    • Volume depletion: Excessive diuretic use, vomiting, diarrhea, or low salt intake can predispose to symptomatic hypotension, especially with the first dose or during titration. Correct volume/salt depletion before starting.
    • Pregnancy: Do not use Diovan during pregnancy. Drugs that act directly on the renin-angiotensin system can cause fetal injury and death, especially in the second and third trimesters. If pregnancy is detected, stop Diovan as soon as possible and contact your healthcare provider.
    • Breastfeeding: Limited data exist. Discuss risks and benefits with your clinician to determine the best antihypertensive strategy during lactation.
    • Surgery/anesthesia: Inform your surgical team you are taking an ARB; perioperative management may be individualized to reduce hypotension risk.
    • Dizziness and driving: Dizziness, lightheadedness, or fatigue can occur, particularly after first doses or dose increases. Use caution when driving or operating machinery until you know how Diovan affects you.

    Contraindications

    Do not take Diovan if you:

    • Have a known hypersensitivity to valsartan or any component of the formulation.
    • Are pregnant or planning pregnancy.
    • Have diabetes and are taking aliskiren; concomitant use increases risks and is contraindicated.

    Use is generally not recommended with aliskiren in patients with renal impairment, and it should be avoided in severe hepatic dysfunction. For patients with bilateral renal artery stenosis or stenosis to a solitary kidney, use requires specialist guidance and close monitoring.

    Possible side effects

    Most people tolerate Diovan well. When side effects occur, they are often mild and transient. Common effects include:

    • Headache, fatigue, or dizziness, particularly when starting treatment or increasing the dose.
    • Upper respiratory symptoms or cough (less common than with ACE inhibitors).
    • Stomach discomfort, nausea, or diarrhea.

    Serious adverse effects are uncommon but require prompt medical attention:

    • Low blood pressure (hypotension): Fainting, severe dizziness, blurred vision, or confusion. Risk is higher with dehydration, diuretics, or a low-salt diet.
    • Kidney dysfunction: Reduced urination, swelling in the legs or ankles, sudden weight gain, or an unexpected rise in creatinine on lab tests.
    • High potassium (hyperkalemia): Muscle weakness, palpitations, slow or irregular heartbeat, or tingling sensations.
    • Angioedema or severe allergic reaction: Swelling of the face, lips, tongue, or throat; difficulty breathing; widespread rash or hives. This is rare with ARBs but requires emergency care.
    • Liver-related effects: Rare elevations in liver enzymes or jaundice; report persistent abdominal pain, dark urine, or yellowing of the skin/eyes.

    If you experience worrisome symptoms, contact your healthcare provider. Seek emergency help for severe reactions such as angioedema, difficulty breathing, syncope, or signs of dangerously high potassium.

    Drug interactions

    Diovan can interact with other medications and supplements. Tell your healthcare team about all prescription drugs, over-the-counter medicines, vitamins, and herbal products you use. Notable interactions include:

    • Other blood pressure drugs: Combining with ACE inhibitors, aliskiren, or additional ARBs is generally not recommended due to increased risk of kidney dysfunction, hyperkalemia, and hypotension. Use with beta-blockers, calcium channel blockers, or thiazide diuretics is common and often beneficial under medical supervision.
    • Potassium-affecting agents: Potassium-sparing diuretics (spironolactone, eplerenone, amiloride), potassium supplements, and salt substitutes can raise potassium levels. Monitor closely if used together.
    • NSAIDs: Ibuprofen, naproxen, and similar drugs may reduce the antihypertensive effect and increase the risk of kidney impairment, particularly in older adults or those with CKD or dehydration. Use the lowest effective NSAID dose for the shortest time, and monitor kidney function as advised.
    • Lithium: ARBs can increase lithium levels and the risk of toxicity. If concomitant use is necessary, assess lithium levels and clinical status frequently.
    • Diuretics and volume-depleting therapies: May potentiate hypotension when initiating or uptitrating valsartan. Correct salt/water depletion beforehand.
    • Alcohol and sedatives: Can amplify dizziness or hypotension. Use cautiously and avoid excessive intake.
    • Herbal/supplement considerations: High-potassium supplements, some protein shakes, and certain salt substitutes can elevate potassium; licorice (true licorice) may affect blood pressure and potassium balance.

    Always consult your clinician before adding or stopping any medication while taking Diovan.

    Missed dose

    If you miss a dose of Diovan, take it as soon as you remember on the same day. If it is almost time for your next scheduled dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at once to make up for a missed dose. To reduce missed doses, consider using reminders or a pill organizer.

    Overdose

    Symptoms of overdose may include pronounced dizziness, fainting from low blood pressure, rapid or slow heartbeat, and in severe cases, circulatory collapse. If you suspect an overdose, call your local poison control center or seek emergency medical attention immediately. Supportive care typically includes laying the person supine with legs elevated, intravenous fluids if needed, and monitoring vital signs and kidney function. Bring the medication container to the emergency department if possible.

    Storage

    Store Diovan at room temperature, ideally 68–77°F (20–25°C). Brief excursions between 59–86°F (15–30°C) are permissible. Keep tablets in their original, tightly closed container, protected from moisture and light. Do not store in bathrooms. Keep out of reach of children and pets. Do not use tablets past their expiration date or if packaging is damaged or shows signs of tampering.

    U.S. Sale and Prescription Policy

    In the United States, Diovan (valsartan) is an FDA-approved prescription medication for hypertension, certain types of heart failure, and improving survival after myocardial infarction. A licensed clinician must evaluate your medical history, current medications, and relevant labs (such as kidney function and potassium) before prescribing and during ongoing use. This ensures safe dosing, appropriate monitoring, and integration with your overall cardiovascular care plan.

    Key points about access and oversight:

    • Prescription requirement: A valid prescription is required to dispense Diovan. Generic valsartan is widely available and often covered by insurance, which can significantly reduce out-of-pocket costs.
    • Monitoring: Periodic checks of blood pressure, kidney function, and electrolytes are recommended, especially after dose changes or when adding interacting medications.
    • Telehealth and pharmacies: Licensed U.S. telehealth providers and community pharmacies can legally dispense Diovan when a clinician issues a prescription after a proper evaluation. Avoid unverified online sources that offer prescription drugs without clinical review.

    HealthSouth Rehabilitation Hospital at MountainView offers a legal and structured solution for acquiring Diovan without a formal prescription in hand by facilitating clinician review and authorization through compliant clinical pathways. This means your medical information is evaluated by a licensed provider who determines appropriateness and issues the necessary order if indicated, ensuring patient safety and regulatory compliance while streamlining access.

    Self-treatment without medical oversight can be dangerous. Always seek professional guidance before starting, stopping, or changing any blood pressure or heart failure therapy.

    Disclaimer

    This content is provided for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition or medications, and before making changes to your treatment plan. While we strive for accuracy and timeliness, no guarantee is made regarding completeness or applicability to your particular circumstances. We are not responsible for any harm resulting from use or misuse of the information provided above.

    Diovan FAQ

    What is Diovan (valsartan), and what is it used for?

    Diovan is the brand name for valsartan, an angiotensin II receptor blocker (ARB) used to treat high blood pressure, heart failure with reduced ejection fraction, and to improve survival after a heart attack by reducing strain on the heart and blood vessels.

    How does Diovan lower blood pressure?

    It blocks angiotensin II type 1 receptors, relaxing blood vessels and reducing aldosterone-driven sodium and water retention, which lowers blood pressure and decreases cardiac workload.

    How long does Diovan take to work?

    You may see some blood-pressure reduction within 1–2 weeks, with full effect typically reached by 4 weeks of consistent daily use.

    How should I take Diovan?

    Take it exactly as prescribed, usually once daily for hypertension (with or without food), and at the same time each day. In heart failure or post–heart attack care, it may be prescribed twice daily. Do not change your dose without your clinician’s guidance.

    What are common side effects of Diovan?

    Dizziness, headache, fatigue, and low blood pressure are most common, especially when starting or increasing the dose. Some people experience mild kidney function changes or elevated potassium.

    What serious side effects should I watch for?

    Seek urgent help for facial, lip, tongue, or throat swelling (angioedema), severe dizziness/fainting, signs of very high potassium (muscle weakness, abnormal heartbeat), or a sudden drop in urine output.

    Who should not take Diovan?

    Do not take it if you are pregnant or planning pregnancy. Avoid combining valsartan with aliskiren if you have diabetes. Use caution in severe kidney or liver disease, bilateral renal artery stenosis, or a history of angioedema. Always review your full medical history with your clinician.

    What medicines interact with Diovan?

    Potassium supplements and salt substitutes, potassium-sparing diuretics (e.g., spironolactone), NSAIDs (e.g., ibuprofen) with chronic use, lithium, and other drugs that affect the renin-angiotensin system can interact. Always check before adding new medications or supplements.

    Do I need lab tests while taking Diovan?

    Yes. Your clinician will typically monitor blood pressure, kidney function (creatinine/eGFR), and potassium, especially after starting or changing the dose, or if you’re at higher risk for kidney issues.

    Can I stop Diovan once my blood pressure is normal?

    Do not stop abruptly. High blood pressure often requires long-term treatment. If your clinician recommends stopping or switching, they will guide a safe plan.

    Is Diovan the same as generic valsartan?

    Yes. Diovan and generic valsartan contain the same active ingredient and work the same way. Generics are typically more affordable; quality-approved generics are considered equivalent.

    Can I take Diovan with food or coffee?

    You can take it with or without food, but be consistent day-to-day. Coffee is acceptable; stay well hydrated and avoid excessive caffeine if it worsens dizziness.

    What should I do if I miss a dose?

    Take it when you remember unless it’s close to your next dose. Do not double up. Resume your regular schedule.

    Does Diovan cause cough like ACE inhibitors?

    Cough is uncommon with ARBs like valsartan and much less frequent than with ACE inhibitors. If you develop persistent cough, report it to your clinician.

    Is Diovan safe for my kidneys?

    By lowering blood pressure, it helps protect kidneys long-term, but it can raise creatinine and potassium in some people, especially with dehydration, NSAIDs, or preexisting kidney disease. Regular monitoring is important.

    Can children take Diovan?

    Valsartan is approved for hypertension in certain children and adolescents (typically 6–16 years), with weight-based dosing. Pediatric use should be supervised by a specialist.

    Can Diovan be split or crushed?

    Some tablets are scored and can be split; do not crush unless your pharmacist confirms it’s safe. A pharmacist-prepared oral suspension may be an option if swallowing tablets is difficult.

    Does Diovan cause weight gain?

    It does not typically cause weight gain. Sudden weight increase could indicate fluid retention from heart failure; report this promptly.

    What is the best time of day to take Diovan?

    Choose a time you can take it consistently (morning or evening). If you feel dizzy after dosing, taking it at bedtime may help.

    Can I drink alcohol while taking Diovan?

    Alcohol can enhance blood pressure-lowering effects and increase dizziness or fainting. If you drink, do so lightly and cautiously, avoid binge drinking, and stand up slowly. Do not drive or operate machinery if you feel lightheaded.

    Is Diovan safe during pregnancy?

    No. Valsartan carries a boxed warning for fetal toxicity, especially in the second and third trimesters. If you become pregnant, stop it immediately and contact your clinician to switch to a pregnancy-safe alternative.

    Can I breastfeed while taking Diovan?

    Because safety data are limited and potential risk exists, especially for newborns, alternatives are generally preferred during breastfeeding. Discuss with your clinician to choose the safest option.

    Should I stop Diovan before surgery?

    Tell your surgeon and anesthesiologist you take an ARB. Many guidelines recommend holding the dose on the morning of major surgery to reduce intraoperative low blood pressure; follow your surgical team’s instructions.

    What if I have vomiting, diarrhea, or dehydration on Diovan?

    These can raise the risk of low blood pressure and kidney injury. Temporarily holding valsartan (“sick day rules”) until you’re rehydrated may be advised; call your clinician for guidance.

    Can I use salt substitutes or potassium supplements with Diovan?

    Avoid potassium-containing salt substitutes and supplements unless specifically prescribed. Valsartan can raise potassium, and excess intake increases the risk of dangerous hyperkalemia.

    Is it safe to take NSAIDs with Diovan?

    Occasional short-term use may be acceptable, but regular NSAID use can blunt blood pressure control and harm kidneys, especially when combined with diuretics. Ask your clinician about safer pain options.

    Can I drive while on Diovan?

    Until you know how it affects you, use caution. If you feel dizzy or lightheaded, avoid driving or operating machinery.

    How does Diovan compare with Cozaar (losartan)?

    Both are ARBs that effectively lower blood pressure and protect the heart. Losartan often has once-daily dosing and may modestly lower uric acid (potentially helpful in gout). Valsartan is widely used in heart failure and post–heart attack care. Choice depends on your conditions, response, and cost.

    Diovan vs Benicar (olmesartan): which is better?

    Both lower blood pressure well. Olmesartan has a rare risk of sprue-like enteropathy (severe chronic diarrhea and weight loss). Valsartan has extensive heart failure and post-MI data. Your clinician will weigh blood pressure goals, side effects, and cost.

    Diovan vs Micardis (telmisartan): what’s the difference?

    Telmisartan has a long half-life, providing smooth 24-hour control and may have modest favorable metabolic effects. Valsartan has strong evidence in heart failure and after MI. Both are good once-daily options; selection often depends on comorbidities and tolerability.

    Diovan vs Avapro (irbesartan): how do they compare?

    Both are effective ARBs. Irbesartan has an FDA indication for diabetic nephropathy in type 2 diabetes with hypertension. Valsartan shines in heart failure and post-MI use. Either can be excellent for blood pressure; kidney, heart, and diabetes factors guide the choice.

    Diovan vs Atacand (candesartan): which is preferred?

    Both control blood pressure and have robust heart failure data. Candesartan is also used off-label for migraine prevention. Dosing schedules differ. Side-effect profiles are similar; final choice is individualized.

    Diovan vs Edarbi (azilsartan): which lowers blood pressure more?

    Head-to-head studies suggest azilsartan can reduce blood pressure slightly more in some patients, but real-world differences are small for many. Cost, availability, and tolerability often drive the decision.

    Diovan vs Teveten (eprosartan): what should I know?

    Both are ARBs; eprosartan is used less commonly and may require twice-daily dosing for some. Efficacy and safety are comparable; convenience and cost typically favor valsartan or other once-daily ARBs.

    Diovan vs losartan for patients with gout: any advantage?

    Losartan can lower uric acid modestly, which may be beneficial in gout-prone patients. Valsartan does not share this effect. If gout is a priority, losartan may be preferred, assuming it meets your blood pressure and cardiac needs.

    Diovan vs olmesartan and the risk of chronic diarrhea?

    Severe, chronic diarrhea with weight loss is a rare but recognized risk with olmesartan (sprue-like enteropathy). This has not been established with valsartan. Report persistent GI symptoms to your clinician.

    Diovan vs telmisartan for 24-hour coverage and adherence?

    Both provide 24-hour control; telmisartan’s long half-life may offer slightly steadier trough levels. If you experience early-morning blood pressure surges, your clinician might consider telmisartan or timing adjustments.

    Diovan vs irbesartan for kidney protection?

    All ARBs can reduce proteinuria and support kidney health by controlling blood pressure. Irbesartan has a specific diabetic nephropathy indication; valsartan may also lower albuminuria but lacks that label. The best option depends on your kidney status and overall risk profile.

    Diovan vs candesartan for heart failure?

    Both improve symptoms and outcomes in heart failure with reduced ejection fraction. Individual response, dosing tolerance, and co-therapies (like beta-blockers and diuretics) often drive selection; either is a guideline-supported choice.

    Diovan vs generic valsartan: is there a difference?

    They contain the same active medicine and are therapeutically equivalent. Generics are typically much less expensive. Use a reputable pharmacy that sources quality-assured products.